2015;125(6):2293C2306. markedly inhibited P493 xenograft growth without affecting mouse expression. Conversely, a Vivo-Morpholino directed at mouse had no antitumor activity in vivo. Collectively, our studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cellCautonomous dependence on GLS for cancer therapy.… Continue reading 2015;125(6):2293C2306

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