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*, < 0.05; **, TAK-242 S enantiomer < 0.01; ***, < 0.001. treatment of YAP-expressing cells induced cell death due to Mcl-1 depletion. In a YAP-associated mouse model of CCA, expression of FGFR 1, 2, and 4 was also significantly increased. Accordingly, BGJ398 treatment was tumor-suppressive in this model and in a YAP-positive PDX model.… Continue reading *, < 0